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Anabolic-androgenic steroids AAS are lipophilic hormones often taken in excessive quantities by athletes and bodybuilders to enhance performance and increase muscle mass. AAS exert well known toxic effects on specific cell and tissue types and organ systems.

The attention that androgen abuse has received lately should be used as an opportunity to educate both athletes and the general population regarding their adverse effects. Among numerous commercially available steroid hormones, very few have been specifically tested for direct neurotoxicity.

Vitality and apoptotic effects were Backpage Armadale shore escort, and immunofluorescence staining and western blot performed. We observe, in contrast to some previous reports but in Body first massage Wagga Wagga ks with others, expression of the androgen receptor AR in neuron-like cells, which when inhibited mitigated the toxic effects of AAS tested, suggesting that the AR could be binding these steroid hormones to induce genomic effects.

We also note elevated transcription of neuritin in treated cells, a neurotropic factor likely expressed in an attempt to resist neurotoxicity. For many years athletes and bodybuilders have been taking AAS in supraphysiological doses in order to attain greatly increased muscle mass, well beyond what can be achieved through natural means Kouri et al.

Intake of AAS by athletes and others in an attempt to gain strength and improve performance is often associated with toxic effects on the liver, the cardiovascular system and the male and female reproductive systems Trifunovic et al.

At the physiological level, there are a wide range of effects of AAS as they possess both anabolic, or muscle-building, and androgenic, or masculinizing, properties Kanayama et al. For example, while AAS use in women is generally uncommon, this population is highly vulnerable Wolllongong the masculinizing effects of AAS and any resulting reproductive changes Malarkey et al.

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